Metabolism and antioxidant activity of serotonin derivatives

研究了两种预防生活方式相关疾病的5-羟色胺衍生物的生物学命运，以评估体内抗氧化活性。经口给药后，在大鼠血浆中检测到这些化合物的完整形式，尽管其血浆浓度较低。相比之下，在血浆中也检测到大量源自原始5-羟色胺衍生物的代谢物，表明这些代谢物可能有助于预防生活方式相关疾病。

Biological fate of two serotonin derivatives which prevent life-style related diseases were examined to evaluate antioxidant activity in vivo. These compounds were detected in rat blood plasma in their intact forms after oral administration, although their plasma concentrations were low levels. In contrast, high amount of metabolites derived from original serotonin derivatives were also detected in blood plasma suggesting possibility that these metabolites contribute prevention of life-style related diseases.