Synthesis of biologically active natural products through highly stereoselective construction of asymmetric quaternary carbon centers and Ugi cyclization

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1) Asymmetric total synthesis of the natural products, furctigenine A, okaramine M, verrucofortine, N-acetylardeemin and so on, was achieved on the basis of developing stereoselective construction of quaternary carbon center and Ugi reaction-cyclization. 2) The structure-activity relationship study was performed by synthesis of some derivatives of N-acetylardeemin, inhibited reversal of multiple drug resistance for anti-cancer agents, and their evaluation of P-glycoprotain inhibitory activity. 3) Stereoselective construction of vicinal quaternary carbon centers was developed to construct a fundamental carbon framework of chimonanthines.