Development and application of a chemiluminescent measurement method folic acid related compounds as an arteriosclerosis marker

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A ruthenium(II)-bipyridine complex chemiluminescent measurement of folic acid related compounds has been examined and developed a useful HPLC-CL method. The developed method was successfully applied to quantify folic acid in tablets and supplements. This means the method might be useful for the quality control of these materials. On the other hand, application of the method to folic acid related compounds except for 5-methyltetrahydrofolic acid in biomaterials was not always successful due to the less stability of these compounds and the lower sensitivity of the method. Improvement of the method concerning the conditions such as stabilizing agent and so on, are required.