Analysis on the function and coalition of RecQL4, a product of a gene mutated in a progeria syndrome, in the DNA transactions.

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In this study, we aimed to understand the function and behavior of RecQL4, a product of a gene mutated in a progeria syndrome, in higher eukaryotic cells. Cell-biological or biochemical analyses of RecQL4 revealed that 1) RecQL4 is promptly translocated onto a site of DNA lesions, 2) RecQL4 interacts with numbers of post-translational modification enzymes, as well as proteins relevant to recognition and repair of DNA lesions, and 3) RecQL4 possesses domains for viability of higher eukaryotic cellsand for coping with DNA damagesin separate regions.