Analysis of molecular mechanism of autophagy by GTP-binding protein Rab32

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Autopagy is a major intracellular protein degradation system involved in eliminating aberrant protein aggregates, protecting against tumors, and defending against pathogen invasion. Here we show that a small GTPase, Rab32, is a novel protein required for the formation of autophagic vacuoles and regulates the clearance of aggregated proteins by autophagy. Although there is a long-standing debate concerning from where the autophagosomal membrane is derived, we found that Rab32 facilitates the formation of autophagic vacuoles whose membranes are derived from the ER and regulates the clearance of aggregated proteins by autophagy.