Analysis of the roles of cyclin D1 in breast cancer stem cells

细胞周期蛋白D1在乳腺癌干细胞中的作用分析

• 批准号: 21590081
• 负责人: SAKAMAKI Toshiyuki
• 金额: $ 2.91万
• 依托单位: Nigata University of Phermacy and Applied Life Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590081/
• 关键词: 遺伝子; 癌; 細胞・組織; シグナル伝達; 蛋白質

Cyclin D1 induces the expression of Dnmt1, Dnmt3a and Dnmt3b, and increases methylation in the promoter region of Musashi1.These results demonstrate that Cyclin D1 may play an important role in tumorigenesis of breast stem cells by epigenetically affecting Notch1 signaling through Musashi1.

Cyclin D1可诱导Dnmt1、Dnmt3a和Dnmt3b的表达，并使Musashi1基因启动子区甲基化程度增加。

项目成果

ErbB2 down-regulates microRNA-205 in breast cancer

• DOI: 10.1016/j.bbrc.2011.07.033
• 发表时间: 2011-08-12
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Adachi, Ryohei;Horiuchi, Shota;Sakamaki, Toshiyuki
• 通讯作者: Sakamaki, Toshiyuki

The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion.

• DOI: 10.1158/0008-5472.can-10-0732
• 发表时间: 2010-12-15
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Liu M;Sakamaki T;Casimiro MC;Willmarth NE;Quong AA;Ju X;Ojeifo J;Jiao X;Yeow WS;Katiyar S;Shirley LA;Joyce D;Lisanti MP;Albanese C;Pestell RG
• 通讯作者: Pestell RG

ErbB2過剰発現乳癌におけるhsa-miR-205の役割の解析

hsa-miR-205在ErbB2过表达乳腺癌中的作用分析

• 发表时间: 2011
• 作者: 安達亮平;堀内翔太;櫻澤喜之;佐藤浩二;酒巻利行
• 通讯作者: 酒巻利行