Study on transcriptional activation mechanism of DJ-1 gene(PARK7) and the trial to Parkinson's disease cure development
Study on transcriptional activation mechanism of DJ-1 gene(PARK7) and the trial to Parkinson's disease cure development
批准号:
21590091
负责人:
TAIRA Takahiro
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
The DJ-1 protein which is a familial Parkinson's disease(PARK7) causative gene product. It was already shown clearly that DJ-1 protein is associated with tyrosine hydroxylase(TH). Although it had been unknown the mechanism of transcriptional activation of TH gene by DJ-1 protein. In this research, We clarified trans-activation mechanism TH gene by DJ-1 protein. Also among human, mouse and rat, it was shown clearly that a mechanism has a difference.
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DOI:
10.3892/ijo_00000451
发表时间:
2009-12-01
期刊:
INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子:
5.2
作者:
[Kim, Yun-Chul, Kitaura, Hirotake, Ariga, Hiroyoshi]
通讯作者:
Ariga, Hiroyoshi
S. M. M.(2009) Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and4-dihydroxy-1-phenylalanine(1-DOPA) decarboxylase with DJ-1
S. M. M.(2009) 通过酪氨酸羟化酶和 4-二羟基-1-苯丙氨酸 (1-DOPA) 脱羧酶与 DJ-1 的相互作用,DJ-1 依赖性多巴胺合成激活的氧化状态
DOI:
--
发表时间:
2009
期刊:
J. Biol. Chem
影响因子:
--
作者:
[Ishikawa, S., Taira, T., Niki, T., Takahashi-Niki, K., Maita, C., Maita, H., Ariga, H. and Iguchi-Ariga]
通讯作者:
H. and Iguchi-Ariga
ヒトDJ-1特異的なチロシン水酸化酵素遺伝子の転写活性化調節
人 DJ-1 特异性酪氨酸羟化酶基因转录激活的调控
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Takahashi K, Murakami M, Hosaka K, Kikuchi H, Oshima Y, Kubohara Y., 石川静麻]
通讯作者:
石川静麻
Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-1-phenylalanine(1-DOPA)decarboxylase with DJ-1
通过酪氨酸羟化酶和 4-二羟基-1-苯丙氨酸 (1-DOPA) 脱羧酶与 DJ-1 的相互作用,DJ-1 依赖性多巴胺合成激活的氧化状态
DOI:
--
发表时间:
2009
期刊:
J.Biol.Chem. 284
影响因子:
--
作者:
[Ishikawa, S.]
通讯作者:
S.
S. M. M.(2009) DJ-1 binds to mitochondrial complex I and maintains its activity.
S. M. M.(2009) DJ-1 与线粒体复合物 I 结合并维持其活性。
DOI:
--
发表时间:
2009
期刊:
Biochem. Biophys. Res. Commun
影响因子:
--
作者:
[Hayashi, T., Ishimori, C., Takahashi-Niki, K., Taira, T., Kim, Y-C., Maita, H., Maita, C., Ariga, H. and Iguchi-Ariga]
通讯作者:
H. and Iguchi-Ariga
共 19 条
Effect of respiratory disease onset and functionality in the alveolar-bronchial of oxidative stress defense protein DJ-1
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批准号:25461184
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.16万
-
财政年份:2013
-
负责人:TAIRA Takahiro
-
依托单位:
Functional analysis of DJ-1, a causative gene product for familial Parkinson's disease
-
批准号:17590049
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2005
-
负责人:TAIRA Takahiro
-
依托单位:
Function of MM-1, a novel c-Myc-binding protein, as a tumor suppressor
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批准号:15590053
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2003
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负责人:TAIRA Takahiro
-
依托单位:
Function of MM-1, a novel c-Myc-binding protein, as a tumor suppressor
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批准号:13672269
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.62万
-
财政年份:2001
-
负责人:TAIRA Takahiro
-
依托单位:
CELL-CYCLE DEPENDENT REGULATION OF HSP70 GENE EXPRESSION BY C-MYC
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批准号:09672207
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.6万
-
财政年份:1997
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负责人:TAIRA Takahiro
-
依托单位:
海外基金