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Study on transcriptional activation mechanism of DJ-1 gene(PARK7) and the trial to Parkinson's disease cure development

Study on transcriptional activation mechanism of DJ-1 gene(PARK7) and the trial to Parkinson's disease cure development
DJ-1基因(PARK7)转录激活机制研究及帕金森病治疗开发尝试
批准号:
21590091
负责人:
TAIRA Takahiro
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
The DJ-1 protein which is a familial Parkinson's disease(PARK7) causative gene product. It was already shown clearly that DJ-1 protein is associated with tyrosine hydroxylase(TH). Although it had been unknown the mechanism of transcriptional activation of TH gene by DJ-1 protein. In this research, We clarified trans-activation mechanism TH gene by DJ-1 protein. Also among human, mouse and rat, it was shown clearly that a mechanism has a difference.
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DOI: 10.3892/ijo_00000451
发表时间: 2009-12-01
期刊: INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子: 5.2
作者: [Kim, Yun-Chul, Kitaura, Hirotake, Ariga, Hiroyoshi]
通讯作者: Ariga, Hiroyoshi
S. M. M.(2009) Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and4-dihydroxy-1-phenylalanine(1-DOPA) decarboxylase with DJ-1
S. M. M.(2009) 通过酪氨酸羟化酶和 4-二羟基-1-苯丙氨酸 (1-DOPA) 脱羧酶与 DJ-1 的相互作用,DJ-1 依赖性多巴胺合成激活的氧化状态
DOI: --
发表时间: 2009
期刊: J. Biol. Chem
影响因子: --
作者: [Ishikawa, S., Taira, T., Niki, T., Takahashi-Niki, K., Maita, C., Maita, H., Ariga, H. and Iguchi-Ariga]
通讯作者: H. and Iguchi-Ariga
ヒトDJ-1特異的なチロシン水酸化酵素遺伝子の転写活性化調節
人 DJ-1 特异性酪氨酸羟化酶基因转录激活的调控
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Takahashi K, Murakami M, Hosaka K, Kikuchi H, Oshima Y, Kubohara Y., 石川静麻]
通讯作者: 石川静麻
Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-1-phenylalanine(1-DOPA)decarboxylase with DJ-1
通过酪氨酸羟化酶和 4-二羟基-1-苯丙氨酸 (1-DOPA) 脱羧酶与 DJ-1 的相互作用,DJ-1 依赖性多巴胺合成激活的氧化状态
DOI: --
发表时间: 2009
期刊: J.Biol.Chem. 284
影响因子: --
作者: [Ishikawa, S.]
通讯作者: S.
19
    Effect of respiratory disease onset and functionality in the alveolar-bronchial of oxidative stress defense protein DJ-1
    • 批准号:
      25461184
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2013
    • 负责人:
      TAIRA Takahiro
    • 依托单位:
    Functional analysis of DJ-1, a causative gene product for familial Parkinson's disease
    • 批准号:
      17590049
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2005
    • 负责人:
      TAIRA Takahiro
    • 依托单位:
    Function of MM-1, a novel c-Myc-binding protein, as a tumor suppressor
    • 批准号:
      15590053
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2003
    • 负责人:
      TAIRA Takahiro
    • 依托单位:
    Function of MM-1, a novel c-Myc-binding protein, as a tumor suppressor
    • 批准号:
      13672269
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.62万
    • 财政年份:
      2001
    • 负责人:
      TAIRA Takahiro
    • 依托单位:
    海外基金