The participation of nicotinic acetylcholine receptor on long lasting psychogenesis induced by repeated electroconvulsive shoc-induced seizure

在本研究中，我们探讨了反复电惊厥(ECS)诱导大鼠癫痫发作的持久心理发生机制。ECS反复诱发的自发交替损伤可能与前额叶皮质、边缘前叶、边缘下缘和CA3区神经元活动有关。电刺激所致的短时记忆障碍与α4β2有关，而与α7烟碱型乙酰胆碱受体无关。因此，可想而知，α-4-β-2烟碱型乙酰胆碱受体激动剂对癫痫患者的记忆障碍有一定的治疗价值。此外，有研究表明，戊四氮点燃的小鼠出现了长期记忆障碍。尽管电惊厥和化学惊厥模型中记忆缺陷的类型有所不同，但两者都被认为是癫痫患者记忆障碍的重要原因。

In this study, we investigated the mechanisms of long lasting psychogenesis induced by repeated electroconvulsive shock(ECS)-induced seizure in rats. The repeated ECS-induced impairment of spontaneous alternation may be related the neuronal activity of the prefrontal cortex(motor2), pre-limbic, infralimbic and CA3 of the hippocampus. ECS-induced impairment of short time memory is related to theα4β2, not butα7 nicotinic acetylcholine receptor. Therefore, it is conceivable thatα4β2 nicotinic acetylcholine receptor agonist is valuable for the memory deficit of epilepsy patients. Furthermore, it is appeared that long term memory deficit is induced by pentylenetetrazol-induced kindled mice. Although there are differences between the type of memory deficits in electric and chemical seizure model, it is thought that both are important for memory deficits of epilepsy patients.