Development of a cancer treatment technique using intracellular collapsing liposomes directed to cancer with double safety systems

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We aimed to develop a novel effective and safe technique for cancer treatment using bacterial toxins with dual safety systems. First, a targeting toxin with safety system and the variable targeting ability was developed. It was confirmed that the liposomes enclosed anticancer drug prepared by using the targeting toxin and anti-carcinoembryonic antigen(CEA) IgG could specifically target to CEA-positive cancer cells and were effective to prolong life of mice inoculated with CEA-positive cancer cells. The second cytotoxic effector toxin with safety system was also produced, so the development of a novel technique for the target-variable cancer treatment using both toxins with safety systems came in sight.