The inhibitory effect of aryl hydrocarbon receptor on spermatogenesis in vivo

在本研究中，我们探讨了AhR激动剂(BaP)抑制体内精子发生的机制。体内分析表明，BaP具有较高的AhR激动剂活性，对精子发生的抑制作用较弱。BaP对精子发生的抑制作用可被AhR拮抗剂α-萘黄酮所消除。这些结果提示AhR参与了BaP对精子发生的抑制作用。

In this study, we investigated the mechanism for the inhibitory effect of AhR agonist(BaP) on spermatogenesis in vivo. BaP showed high AhR agonist activity and weak inhibitory effect on spermatogenesis in vivo analysis. The inhibitory effect of BaP on spermatogenesis was abolished by co-treatment with an AhR antagonist, a-naphthoflavone. These results suggest that AhR is involved in the inhibition of spermatogenesis by BaP.