The inhibitory effect of aryl hydrocarbon receptor on spermatogenesis in vivo

本研究探讨了AhR激动剂（BaP）抑制精子发生的机制。体内实验表明BaP具有较高的AhR激动活性，但对精子发生的抑制作用较弱。BaP对精子发生的抑制作用可通过与AhR拮抗剂α-萘酚酮共同处理而消除。这些结果表明AhR参与了BaP对精子发生的抑制作用。

In this study, we investigated the mechanism for the inhibitory effect of AhR agonist(BaP) on spermatogenesis in vivo. BaP showed high AhR agonist activity and weak inhibitory effect on spermatogenesis in vivo analysis. The inhibitory effect of BaP on spermatogenesis was abolished by co-treatment with an AhR antagonist, a-naphthoflavone. These results suggest that AhR is involved in the inhibition of spermatogenesis by BaP.