Analysis of dissolution kinetics and first-pass elimination of orally administered drugs and its application to prediction of absorption behavior after oral administration

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The large variability in absorption behavior of griseofulvin would be attributed to the large variability in in vivo dissolution behavior after oral administration. We successfully described the individual absorption behavior of griseofulvin based on the data of gastrointestinal transit and the estimated in vivo dissolution behavior. SMEDDS significantly increased the bioavailability and reduced the interindividual difference in absorption behavior of griseofulvin. Both CYP3A and P-gp significantly contributed to the intestinal extraction of digoxin, but neither would affect the absorption clearance.