Morphological and molecular backgrounds for localization of ATP-induced signals in glial cells associated with cutaneous sensory devices.

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Glial cells in cutaneous sensory devices extend multiple lamellar processes that cover different axon terminals and generate their own Ca^2+ signals in response to stimulation with the neurotransmitter ATP. We examined links between this glial signaling and the plasma membrane microdomains caveolae by immunohistochemistry and Ca^2+ image analysis in isolated lanceolate sensory endings. motion detectors of rat vibrissae. Our data have shown that caveola-dependent localization of the ATP receptor P2Y_2 and its coupling partner G_q/11 to the glial lamellae is essential for the subcellular compartmentalization of the signals.