Analysis of regulatory mechanisms of cell surface expression of Histamine H3 receptor

点击翻译按钮获取中文摘要

Histamine H3 receptor has drawn much attention in research community as a potential drug target for sleep wake disorder, eating disorder, and learning-memory disorders. Histamine H3 receptor belongs to the G protein-coupled receptor family and the receptor protein should be transported correctly from ER to cell surface after transcription and translation of the receptor gene in order for the receptor to function properly. This research identified various cellular proteins that interact with carboxy-terminus of Histamine H3 receptor and showed that these proteins regulate the transport of the receptor molecule to the cell surface