Analysis of regulatory mechanisms of cell surface expression of G protein-coupled receptor signaling complex

G蛋白偶联受体(GPCRs)是许多临床重要药物的分子靶点。为了在细胞表面正常发挥功能，在核糖体合成GPCRs后，受体必须以受体-信号分子复合体的形式有效地转运到细胞表面。本研究鉴定了几种与GPCRs羧基末端相互作用的细胞蛋白，并表明这些相互作用的蛋白调节同源GPCRs的运输和细胞表面表达。

G protein-coupled receptors (GPCRs) have been well known as molecular targets for many clinically important drugs. In order to function properly at cell surface, the receptors have to be transported efficiently as receptor-signaling molecule complexes to the cell surface after the GPCRs are synthesized at ribosomes. This research identified several cellular proteins that interact with carboxy-termini of GPCRs and showed that these interacting proteins regulate the transport and the cell surface expression of the cognate GPCRs.