A crosstalk between sensory neurons and surrounding cells

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To examine mechanisms underlying substance P(SP) release from primary sensory neurons in response to activation of the nonselective cation channel transient receptor potential ankyrin 1(TRPA1), SP release from cultured rat dorsal root ganglion(DRG) neurons was measured, using radioimmunoassay, by stimulating TRPA1 with allyl isothiocyanate(AITC). The data suggest that activation of TRPA1 evokes SP release from the primary sensory neurons through phosphorylation of p38 MAP kinase, subsequent nociceptive behaviors and inflammatory responses. Furthermore, the data also indicate that blocking the effects in periphery tissue of TRPA1 activation leads to significant antinociception.