PPARγplays an important role in improvement of cognitive decline in Alzheimer's disease model animals complicated by lifestyle deseases.

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We made Alzheimer's disease model animals to complicate cerebrovascular disorders, and we proved that defects of memory such as the maze learning disability aggravated. It was supposed that the temporal increase of inflammatory cytokines including TNFα and HMGB1 and apoptosis of neurons in the hippocampus CA1 leaded with the onset of dementia by the cerebrovascular disorders. Furthermore, We were able to improve a spatial memory disorder by activating PPARγwith anti-inflammatory effect and anti-apoptosis effect. It was proved that drugs with PPARγ agonist effect could become the dementia therapeutic drug than this study.