Protective participation of ATP/adenosine axis on the dilated cardiomyopathy of the life-style related diseases model animal.

ATP/腺苷轴对生活方式相关疾病模型动物扩张型心肌病的保护作用。

• 批准号: 21590296
• 负责人: SHINOZUKA Kazumasa
• 金额: $ 2.83万
• 依托单位: Mukogawa Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590296/
• 关键词: 中枢・末梢神経系; 虚血再灌流; ラット心室筋; ATP放出; アデノシン放出; 交感神経機能; ノルアドレナリン遊離; 低酸素; SHRSP.Z-Lepr^<fa>/IzmDmcrラット; プレコンディショナル; ATP; アデノシン; SHR.Z-Lepr^<fa>/IzmDmcrラット; 拡張機能障害; 心交感神経; 低酸素状態; ニコランジル; SHRSP.Z-Lepr^<fa>; IzmDmcrラット; 虚血プレコンディショナル; 拡張機能障害心

The release of adenosine/ATP from cardiac muscle and the release of noradrenaline from sympathetic nerves were increased by hypoxia. The release of noradrenaline in the condition of hypoxia was significantly inhibited by adenosine(10μM). Adenosine receptor antagonist, 8SPT(30μM) did not influence the release of noradrenaline under the condition of hypoxia. More study is necessary to clarify role of endogenous adenosine on the noradrenaline release under the hypoxic condition.

心肌腺苷/ATP释放和交感神经去甲肾上腺素释放增加。腺苷（10μM）可明显抑制缺氧条件下去甲肾上腺素的释放。腺苷受体拮抗剂8 SPT（30μM）对缺氧条件下去甲肾上腺素的释放无影响。内源性腺苷在缺氧条件下去甲肾上腺素释放中的作用有待进一步研究。

项目成果

Involvement of oxidative stress in impared vasodilation of coronary arteries in SHRSP. Z-Lepr^<fa>/IzmDmcr, an animal model of metabolic syndrome

SHRSP 中氧化应激参与冠状动脉血管舒张受损。

• 发表时间: 2009
• 作者: Satomi Kagota;Yukari Tada;Kazuhito Fukushima;Keiji Umetani;Kazuki Namakumra;Masaru Kunitomo;Kazumasa Shinozuka
• 通讯作者: Kazumasa Shinozuka

Effect of vanadate on ATP-induced increase in intracellular calcium ion levels in human umbilical vein endothelial cells

钒酸盐对ATP诱导的人脐静脉内皮细胞胞内钙离子水平升高的影响

• 发表时间: 2010
• 期刊: Biol Pharm Bull
• 影响因子: 2
• 作者: Nejime N;Tada Y;Kagota S;Tanabe Y;Hashimoto M;Shinozuka K
• 通讯作者: Shinozuka K

Effect of vanadate on ATP-induced increase in intracellular calcium ion levels in human umbilical vein endothelial cells.

钒酸盐对 ATP 诱导的人脐静脉内皮细胞细胞内钙离子水平增加的影响。

• 发表时间: 2010
• 期刊: Biol Pharm Bull. (In press)
• 作者: Nejime N;et al.
• 通讯作者: et al.

Characterization of Cardiac Size and Function in SHRSP Z-Leprfa/IzmDmcr Rats, a New Animal Model of Metabolic Syndrome

• DOI: 10.1248/bpb.33.1971
• 发表时间: 2010-12-01
• 期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 2
• 作者: Tada, Yukari;Kagota, Satomi;Shinozuka, Kazumasa
• 通讯作者: Shinozuka, Kazumasa

Effects of nicorandil on sympathetic neurotransmission in rat caudal artery

尼可地尔对大鼠尾动脉交感神经传递的影响

• 发表时间: 2010
• 期刊: Clin Exp Pharmacol Physiol
• 作者: Tei A;Nejime N;Tada Y;Kagota S;Tanabe Y;Hashimoto M;Shinozuka K
• 通讯作者: Shinozuka K