Protective participation of ATP/adenosine axis on the dilated cardiomyopathy of the life-style related diseases model animal.

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The release of adenosine/ATP from cardiac muscle and the release of noradrenaline from sympathetic nerves were increased by hypoxia. The release of noradrenaline in the condition of hypoxia was significantly inhibited by adenosine(10μM). Adenosine receptor antagonist, 8SPT(30μM) did not influence the release of noradrenaline under the condition of hypoxia. More study is necessary to clarify role of endogenous adenosine on the noradrenaline release under the hypoxic condition.