Analysis of interchromosomal effect in human using yeast model

高比例配子的产生与不平衡的遗传补体密切相关，并导致自然流产和异常后代的风险增加。报道了与易位染色体无关的染色体异常，并将其命名为染色体间效应（ICE）。然而，ICE的存在仍然是一个争议的来源，一些研究观察到这种影响，而另一些则没有。在这个项目中，我使用染色体易位酵母模型分析了ICE。因此，ICE的存在或大小可能受到重排特征的影响。

The production of a high proportion of gametes with an unbalanced genetic complement is strictly related to translocations and causes an increased risk of spontaneous abortions and abnormal offspring. The chromosomal abnormalities unrelated to the translocation chromosomes were reported, and it was named as an interchromosomal effect(ICE). However, the existence of the ICE has remained a source of controversy with some studies observing such an effect, whereas others have not. In this project, I analyzed the ICE using a chromosomal translocation yeast model. As a result, the existence or magnitude of the ICE may be influenced by the characteristics of the rearrangement.