Novel approach to liver disease from aspect of cellular senescence

本研究揭示了细胞衰老与原发性胆汁性肝硬变等肝病的发病机制有关。在PBC的炎症和损伤的小胆管中，衰老的胆管上皮细胞显示CCR2和CX3CL1等趋化因子表达增加。体外培养的衰老胆管上皮细胞表达多种趋化因子，并诱导单核细胞和肝星状细胞迁移。这些结果提示，衰老的胆管上皮细胞可能通过调节PBC的微环境而在胆管周围的炎症反应中发挥作用。

This study revealed that cellular senescence is involved in the pathogenesis of liver diseases such as primary biliary cirrhosis(PBC). Senescent biliary epithelial cells in inflamed and damaged small bile ducts in PBC show increased expression of chemokines such as CCR2 and CX3CL1. Cultured senescent biliary epithelial cells showed increased expression of various chemokines and induced migration of monocytes and hepatic stellate cells in co-culture. These findings suggests that senescent biliary epithelial cells may play a role in augmentation of inflammation around bile ducts by regulating microenvironment in PBC.