Molecular mechanisms of promotion or suppression in renal tubular interstitial fibrosis

促进或抑制肾小管间质纤维化的分子机制

• 批准号: 21590444
• 负责人: MURAGAKI Yasuteru
• 金额: $ 3万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590444/
• 关键词: 疾患モデル動物; 線維化; 上皮間葉転換; TGF-β; 腎尿細管; TGF-βシグナル; EMT; TRPS1; Smad3; 腎; Trps1; Arkadia; Smad7; Trpsl

Mutations in TRPS1 cause tricho-rhino-pharyngeal syndrome. Trps1 is essential for nephron development, acting downstream of Bmp7. Because Bmp7 counteracts epithelial-to-mesenchymal transition(EMT) and reverses chronic renal injury, we examined the function of Trps1 in renal fibrosis. The results of the experiment suggest that Trps1 deficiency enhances TGF-b1-induced EMT and tubulointestinal fibrosis by modulating the amount of Smad7 through Arkadia/ubiquitin-mediated degradation.

TRPS1 突变会导致毛鼻咽综合征。 Trps1 对于肾单位发育至关重要，作用于 Bmp7 下游。由于 Bmp7 可以抵消上皮间质转化 (EMT) 并逆转慢性肾损伤，因此我们检查了 Trps1 在肾纤维化中的功能。实验结果表明，Trps1 缺陷通过 Arkadia/泛素介导的降解调节 Smad7 的量，从而增强 TGF-b1 诱导的 EMT 和小管肠纤维化。

项目成果

Occurrence of Central Polydactyly, Syndactyly, and Cleft Hand in a Single Family: Report of Five Hands in Three Cases

• DOI: 10.1016/j.jhsa.2009.06.010
• 发表时间: 2009-11-01
• 期刊: JOURNAL OF HAND SURGERY-AMERICAN VOLUME
• 影响因子: 1.9
• 作者: Satake, Hiroshi;Ogino, Toshihiko;Kano, Hiroki
• 通讯作者: Kano, Hiroki

Renal interstitial fibrosis is promoted through an elevated amount of Arkadia in heterozygous loss of Trpsl.

Trpsl 杂合缺失中 Arkadia 含量升高会促进肾间质纤维化。

• 发表时间: 2010
• 作者: Gai Z;Gui T;Itoh S;Oikawa K;Uetani K;Muragaki Y.
• 通讯作者: Muragaki Y.

Trps1 Functions Downstream of Bmp7 in Kidney Development

• DOI: 10.1681/asn.2008091020
• 发表时间: 2009-11-01
• 期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
• 影响因子: 13.6
• 作者: Gai, Zhibo;Zhou, Gengyin;Muragaki, Yasuteru
• 通讯作者: Muragaki, Yasuteru

The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition.

• DOI: 10.1155/2012/289243
• 发表时间: 2012
• 期刊: Journal of signal transduction
• 作者: Gui T;Sun Y;Shimokado A;Muragaki Y
• 通讯作者: Muragaki Y

Tolvaptan, a selective oral vasopressin V2 receptor antagonist, ameliorates podocyte injury in puromycin aminonucleoside nephrotic rats

• DOI: 10.1007/s10157-009-0196-0
• 发表时间: 2009-10-01
• 期刊: CLINICAL AND EXPERIMENTAL NEPHROLOGY
• 影响因子: 2.3
• 作者: Okada, Tadashi;Sakaguchi, Toshifumi;Shigematsu, Takashi
• 通讯作者: Shigematsu, Takashi