Analysis of immunosuppression mechanism by sialic acids on cancer cells, and a feasible study to control immune reaction using sialylated carbohydrates.

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This study was conducted to increase knowledge about immune evasion by cancer cells, focusing on appearing sialic acids(Sialyl Tn antigen) with development and progression of cancer. Using xenotransplantation and syngenic transplantation animal models, and sialic acid coated liposome, we demonstrated that sialic acids had regulatory function to suppress tumor immunity. Additionally, we established methods to generate a series of immortalized cells that are available to investigate further mechanism of immune evasion.