Elucidation of the molecular mechanism how EB virus induces the pathogenesis by visualizing viral infection

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Epstein-Barr virus is an oncogenic herpesvirus that infects into over 90% of worldwide human beings. To elucidate the molecular pathogenesis in which EB virus induce cell growth transformation, recombinant EB virus was produced to visualize the viral infection and then utilized for identification of host factor that is responsible for the viral entry. Furthermore, the novel cloning strategy for identifying host molecules associated with latent membrane proteins was established to clarify the contribution of the interacting host factor in EB virus infection.