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The role of Notch signaling in the development and maintenance of memory T cells

The role of Notch signaling in the development and maintenance of memory T cells
Notch 信号在记忆 T 细胞发育和维持中的作用
批准号:
21590536
负责人:
MAEKAWA Yoichi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Immunological memory is essential for providing protection against recurrent infection. However, it is still unknown the molecular mechanism underlying the development and maintenance of memory T cells. Here, we found that the mice bearing Notch signaling-deficient T cells did not show the protective immune response against secondary Leishmania major infection, indicating that Notch signaling is critical for memory T cell survival after antigen stimulation.
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The Lifestyle of the Segmented Filementous Bacterfum : A Non-Culturable Cut-Associated Immunostimulating Mlcrobe Inferred by Whole-Genome Sequencing
分段丝状细菌的生活方式:全基因组测序推断的不可培养的切割相关免疫刺激微生物
DOI: --
发表时间: 2011
期刊: DNA Res
影响因子: 4.1
作者: [Kuwahara T, et al]
通讯作者: et al
DOI: 10.1073/pnas.0911755107
发表时间: 2010-03-30
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子: 11.1
作者: [Alam, Muhammad Shamsul, Maekawa, Yoichi, Yasutomo, Koji]
通讯作者: Yasutomo, Koji
Manipulation of CD98 resolves Type 1 diabetes in NOD mice
CD98 的操作可解决 NOD 小鼠的 1 型糖尿病问题
DOI: --
发表时间: 2012
期刊: J Immunol
影响因子: 4.4
作者: [Gaojian L, et al]
通讯作者: et al
DOI: 10.1093/dnares/dsr022
发表时间: 2011-08
期刊: DNA research : an international journal for rapid publication of reports on genes and genomes
影响因子: --
作者: [Kuwahara T, Ogura Y, Oshima K, Kurokawa K, Ooka T, Hirakawa H, Itoh T, Nakayama-Imaohji H, Ichimura M, Itoh K, Ishifune C, Maekawa Y, Yasutomo K, Hattori M, Hayashi T]
通讯作者: Hayashi T
14
    Manipulation of pathogenic memory T cells for development of novel treatment for food allergy
    • 批准号:
      16K15524
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.16万
    • 财政年份:
      2016
    • 负责人:
      MAEKAWA Yoichi
    • 依托单位:
    Comprehensive understandings of host immunological memory mechanism to develop an effective vaccine strategy for leishmaniasis
    • 批准号:
      15H04724
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.98万
    • 财政年份:
      2015
    • 负责人:
      MAEKAWA Yoichi
    • 依托单位:
    Notch signal controls the survival of memory CD4+ T cells
    • 批准号:
      24590585
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      MAEKAWA Yoichi
    • 依托单位:
    海外基金