The role of Notch signaling in the development and maintenance of memory T cells
The role of Notch signaling in the development and maintenance of memory T cells
批准号:
21590536
负责人:
MAEKAWA Yoichi
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Immunological memory is essential for providing protection against recurrent infection. However, it is still unknown the molecular mechanism underlying the development and maintenance of memory T cells. Here, we found that the mice bearing Notch signaling-deficient T cells did not show the protective immune response against secondary Leishmania major infection, indicating that Notch signaling is critical for memory T cell survival after antigen stimulation.
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The Lifestyle of the Segmented Filementous Bacterfum : A Non-Culturable Cut-Associated Immunostimulating Mlcrobe Inferred by Whole-Genome Sequencing
分段丝状细菌的生活方式:全基因组测序推断的不可培养的切割相关免疫刺激微生物
DOI:
--
发表时间:
2011
期刊:
DNA Res
影响因子:
4.1
作者:
[Kuwahara T, et al]
通讯作者:
et al
DOI:
10.1073/pnas.0911755107
发表时间:
2010-03-30
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子:
11.1
作者:
[Alam, Muhammad Shamsul, Maekawa, Yoichi, Yasutomo, Koji]
通讯作者:
Yasutomo, Koji
Manipulation of CD98 resolves Type 1 diabetes in NOD mice
CD98 的操作可解决 NOD 小鼠的 1 型糖尿病问题
DOI:
--
发表时间:
2012
期刊:
J Immunol
影响因子:
4.4
作者:
[Gaojian L, et al]
通讯作者:
et al
DOI:
10.1093/dnares/dsr022
发表时间:
2011-08
期刊:
DNA research : an international journal for rapid publication of reports on genes and genomes
影响因子:
--
作者:
[Kuwahara T, Ogura Y, Oshima K, Kurokawa K, Ooka T, Hirakawa H, Itoh T, Nakayama-Imaohji H, Ichimura M, Itoh K, Ishifune C, Maekawa Y, Yasutomo K, Hattori M, Hayashi T]
通讯作者:
Hayashi T
Notch signaling controls T cell homeostasis
Notch 信号传导控制 T 细胞稳态
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Fukasawa M, Shirasago Y, Saito K, Murakami Y, Fukazawa H, Suzuki T, Suzuki R, Wakita T, Hanada K, Chiba J, Ohkura N. et al., 前川洋一, 前川洋一]
通讯作者:
前川洋一
共 14 条
Manipulation of pathogenic memory T cells for development of novel treatment for food allergy
-
批准号:16K15524
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.16万
-
财政年份:2016
-
负责人:MAEKAWA Yoichi
-
依托单位:
Comprehensive understandings of host immunological memory mechanism to develop an effective vaccine strategy for leishmaniasis
-
批准号:15H04724
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.98万
-
财政年份:2015
-
负责人:MAEKAWA Yoichi
-
依托单位:
Notch signal controls the survival of memory CD4+ T cells
-
批准号:24590585
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2012
-
负责人:MAEKAWA Yoichi
-
依托单位:
海外基金