Mechanisms of T cell activation regulation by inhibitory microclusters

抑制性微簇调节T细胞活化的机制

• 批准号: 21590548
• 负责人: YOKOSUKA Tadashi
• 金额: $ 3万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590548/
• 关键词: 免疫学; シグナル伝達; 分子イメージング; T細胞受容体; 補助刺激受容体; 抗原認識; リンパ球; バイオイメージング; 受容体・細胞内シグナル伝達; 獲得免疫

Imaging analysis of the negative costimulatory receptor, CTLA-4, revealed the novel mechanism of T cell activation regulation. CTLA-4 formed clusters at the center of the immunological synapse and interfered the formation of the signaling molecule complex, which is composed by the positive costimulatory receptor CD28, kinases, and scaffold proteins. These results suggest that T cell activation is cooperatively regulated by both T cell receptor. CD28 microclusters and the CTLA-4-mediated inhibitory microclusters.

负共刺激受体 CTLA-4 的成像分析揭示了 T 细胞激活调节的新机制。 CTLA-4在免疫突触中心形成簇，干扰信号分子复合物的形成，该信号分子复合物由正共刺激受体CD28、激酶和支架蛋白组成。这些结果表明 T 细胞活化是由两种 T 细胞受体协同调节的。 CD28 微簇和 CTLA-4 介导的抑制性微簇。

项目成果

SH3-Guk domain regulating Carma1 micro-cluster formation is essential for antigen receptor-induced NF-κB activation

SH3-Guk 结构域调节 Carma1 微簇形成对于抗原受体诱导的 NF-κB 激活至关重要

• 发表时间: 2011
• 作者: Yokosuka T;Saito T;Hiromitsu Hara
• 通讯作者: Hiromitsu Hara

Spatiotemporal regulation of T cell co-stimulation

T细胞共刺激的时空调节

• 发表时间: 2011
• 作者: Saito;T.;Yokosuka;T.;Tane-Hashimoto;A.
• 通讯作者: A.

Dynamic regulation of T-cell costimulation by TCR microclusters and the c-SMAC

TCR 微簇和 c-SMAC 对 T 细胞共刺激的动态调节

• 发表时间: 2009
• 作者: Yusuke Hayashi;Jacqueline Bourdeau;Riichiro Mizoguchi;Tadashi Yokosuka
• 通讯作者: Tadashi Yokosuka

Imaging of T cell activation regulation : -Negative regulation of TCR signaling by PD-1 microcluster-

T 细胞激活调节的成像：-PD-1 微簇对 TCR 信号传导的负调节-

• 发表时间: 2011
• 作者: Shimizu K;Asakura M;Sugahara H;Shinga J;Fujii S;Takashi Saito
• 通讯作者: Takashi Saito

The PD-1 microclusters : negative costimulatory signalosome directly targeting TCR downstream

PD-1微簇：直接靶向TCR下游的负共刺激信号体

• 发表时间: 2011
• 作者: Watarai H;Sekine-Kondo E;Shigeura T;Motomura Y;Yasuda T;Satoh R;Yoshida H;Kubo M;Kawamoto H;Koseki H;Taniguchi M;Tadashi Yokosuka
• 通讯作者: Tadashi Yokosuka