Anti-atherogenicity of increased levels of HDL caused by angiopoietin-like protein gene mutations

血浆高密度脂蛋白水平升高经常出现在约1%的日本普通人群中。除CETP缺乏外，高密度脂蛋白水平的遗传原因尚不清楚。血浆血管生成素样蛋白3和4分别是脂蛋白脂肪酶和内皮脂肪酶的内源性脂肪酶抑制因子。虽然在高密度脂蛋白水平升高但没有CETP缺陷的受试者中对这两个基因的每个外显子进行了筛查，但没有发现突变。

Increased levels of plasma HDL is frequently found in~ 1% of general Japanese population. Genetic cause of high HDL levels has been uncertain except CETP deficiency. Plasma angiopoietin-like protein 3 and 4 are known as an intrinsic lipase inhibitor against lipoprotein lipase and endothelial lipase, respectively. Although every exon in these two genes was screened in subjects with increased HDL levels but without CETP deficiency, mutation was not found.