Studies on the early cancer detection with urinary diacetylspermine and its application

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N^1, N^<12>-diacetylspermine(DiAcSpm) in urine is frequently increased in cancer patients at earlier stages of the disease and hence is considered as promising tumor marker. In the present study we first analyzed the urinary DiAcSpm level of healthy persons in detail, and established cut-off values to distinguish between normal and abnormal levels of DiAcSpm excretion. We then developed an immunochromatographic device for simple and rapid DiAcSpm determination. The spreading of this simple determination procedure may help in increasing the opportunity of early detection of cancer patients. Our further analysis revealed that DiAcSpm is increased in cancer tissues from very early stages of cancer development. This finding provides us with a new method for early cancer detection on one hand, and a useful clue to answer the question of why DiAcSpm is increased in the urine from early cancer patients.