Establishment of biomarker panel for the early detection of atherosclerosis and the prevention of the cardio-renal syndromes in obesity and metabolic syndrome-role of the phenotypes and the function of peripheral blood monocytes-

我们发现单核细胞的表型（炎症M1型和抗炎M2型：质变）与已知的心血管风险显著相关，并且日本国家医院组织数据库中1050名肥胖和代谢综合征患者的外周血单核细胞不利的促炎(M1)/抗炎（M2）样表型通过糖尿病或抗高脂血症药物治疗得到改善。因此，这些数据表明单核细胞表型测量在早期检测动脉粥样硬化和预防肥胖和代谢综合征的心血管疾病方面的有效性。

We have revealed that the phenotypes of monocyte(inflammatory M1 type and anti-inflammatory M2 type : qualitative changes) are significantly associated with the known cardiovascular risks and that unfavorable pro-inflammatory(M1)/anti-inflammatory(M2)-like phenotypes of peripheral blood monocytes are improved by the treatment with diabetic or anti-hyperlipidemic drugs in Japanese patients with obesity and metabolic syndrome from 1050 subjects in the database of National Hospital Organization. Accordingly, these data suggest the efficacy of the measurement of phenotypes of monocytes for early detection of atherosclerosis and the prevention of cardiovascular diseases in obesity and metabolic syndrome.