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Immunological tolerance induced by Kampo medicine kakkonto through the regulation of helper T cell differentiation in the mucosal immune system of the intestine.

Immunological tolerance induced by Kampo medicine kakkonto through the regulation of helper T cell differentiation in the mucosal immune system of the intestine.
汉方药物 kakkonto 通过调节肠道粘膜免疫系统中辅助 T 细胞的分化诱导免疫耐受。
批准号:
21590760
负责人:
KADOWAKI Makoto
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
The mechanisms underlying the pharmacological effects of kakkonto in murine food allergy model were examined. As a result, kakkonto facilitated the differentiation from naive helper T cells to CD25 negative CD3+CD4+FR4+Foxp3+T cells in the immunological responses within the mucosal immune system of the intestine and thereby alleviated the allergic responses. However, the further detailed investigation of the underlying mechanisms is needed.
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会议论文
DOI: 10.1016/j.bbrc.2011.11.014
发表时间: 2011-12-16
期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子: 3.1
作者: [Kageyama-Yahara, Natsuko, Wang, Xiaoyu, Kadowaki, Makoto]
通讯作者: Kadowaki, Makoto
DOI: 10.1248/bpb.34.760
发表时间: 2011-05-01
期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
影响因子: 2
作者: [Kageyama-Yahara, Natsuko, Suehiro, Yoko, Kadowaki, Makoto]
通讯作者: Kadowaki, Makoto
Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo.
五没食子酰葡萄糖在体外和体内下调肥大细胞表面 FcepsilonRI 表达。
DOI: --
发表时间: 2010
期刊: FEBS Lett 584
影响因子: --
作者: [Kageyama-Yahara N, Suehiro Y, Maeda F, Kageyama S, Fukuoka J, Katagiri T, Yamamoto T, Kadowaki M.]
通讯作者: Kadowaki M.
食物アレルギー性消化器症状誘発病態モデルにおける葛根湯による制御性T細胞への分化亢進を介する腸管粘膜免疫系の制御機構
在食物过敏胃肠道症状的病理模型中Kakkonto增强调节性T细胞分化介导的肠粘膜免疫系统的控制机制
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [小川朝生, 内富庸介, 山本武]
通讯作者: 山本武
10
    Pathophysiological Role of Cholinergic Anti-inflammatory Pathway via Nicotinic Acetylcholine Receptors in Experimental Ulcerative Colitis
    • 批准号:
      18590507
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.45万
    • 财政年份:
      2006
    • 负责人:
      KADOWAKI Makoto
    • 依托单位:
    Food allergy and immunologic disease in the intestine : the role of primary afferent neurons in the intestine
    海外基金