Maintaining an ideal body weight and stress response

中央给药尿皮质素3（Ucn3）降低胃排空率，破坏有意识食物剥夺小鼠的胃窦和十二指肠运动活动。慢性心理应激破坏了有意识剥夺食物的大鼠的空腹运动。慢性心理应激使下丘脑Ucn3 mRNA表达增加。脑室内给药Ucn3抗血清可预防慢性心理应激引起的心窦运动改变。Ucn3和促肾上腺皮质激素释放因子受体2可能是治疗应激相关疾病的有希望的靶点。

Centrally administered urocortin 3(Ucn3) decreased gastric emptying rate and disrupted motor activity in the antrum and duodenum of conscious food-deprived mice. Chronic psychological stress disrupted the fasted motility in the antrum of conscious food-deprived rats. mRNA expression of Ucn3 in the hypothalamus was increased by chronic psychological stress. Intracerebroventricular administration of Ucn3 antiserum prevented alteration in antral motility induced by chronic psychological stress. Ucn3 and corticotrophin releasing factor-receptor 2 may be promising targets for the treatment of stress-related diseases.