Effects of early statin treatment on circulating inflammatory biomarkers and progressing stroke.

共纳入146例缺血性脑卒中患者，分为他汀类药物组（阿托伐他汀，10 mg/d，发病后48 h内开始）和非他汀类药物组（他汀类药物停药2周）。早期他汀类药物治疗显著降低了IL-6的血清水平（p=0.047）和入院后14天内神经功能恶化的频率（p=0.035）。他汀类药物治疗48小时内降低IL-6升高，并可能防止早期神经功能恶化。

A total of 146 ischemic stroke patients were enrolled and were divided into Statin Group(atorvastatin, 10 mg daily, initiated within 48 hrs after the onset) and Non-Statin Group(statin was not administered for 2 weeks). Early statin treatment significantly lowered the serum levels of IL-6(p=0.047) and frequency of neurological deterioration during 14 days after admission(p=0.035). Statin treatment within 48 hrs decreases IL-6 elevation and may protect against early neurological deterioration.