Intestinal environmental control by using a newly-produced biopolymer during the progression of acute pancreatitis.

我们研究了一种新开发的生物聚合物聚-(R)-3-羟基丁酸酯(PHB)是否在肠内外环境中对急性胰腺炎的进展具有预防作用。PHB对重症急性胰腺炎大鼠的细菌易位有明显的保护作用。PHB对肠道菌群和肠道数量均有影响，但不改变粪便有机酸组成。确切的机制尚不清楚，但口服PHB的肠道发酵可能成为治疗急性胰腺炎侵袭性肠道损害的一种新方法。

We investigated if Poly-(R)-3-hydroxybutyrate(PHB), a newly-developed biopolymer, had a preventive effect against the progression of acute pancreatitis with regard to intra-and extra-intestinal environment. PHB showed significant protective activity toward the bacterial translocation in rats with severe acute pancreatitis. PHB affected both bowel flora and bowel amount without altering fecal organic acid composition. The precise mechanism remains unknown, but the intestinal fermentation of oral PHB might become a novel treatment for invasive intestinal involvement in acute pancreatitis.