Effect of Angiotensin II Type I Receptor Gene Polymorphism on Cardiac Events in Patients with Hypertension

血管紧张素II I型受体基因多态性对高血压患者心脏事件的影响

• 批准号: 21590894
• 负责人: SATO Hiroshi
• 金额: $ 2.91万
• 依托单位: Kwansei Gakuin University (2010-2011)Osaka University (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590894/
• 关键词: 臨床心血管病態学; 心筋梗塞; 遺伝子多型; レニンアンジオテンシン系; 高血圧; マイクロRNA; アンジオテンシン

Clinical impact of polymorphism of angiotensin receptor gene(AT1R(1166A→C)) was examined in discharged patients with acute myocardial infarction. This polymorphism related with increased risk for cardiac death especially in patients with hypertension. Furthermore, MicroRNA155, which reduces translation of ATIR, was elevated in patients with cardiac death early after discharge.

研究急性心肌梗死患者血管紧张素受体基因（AT1R）1166A→C多态性与临床的关系。该基因多态性与心源性死亡风险增加相关，尤其是在高血压患者中。此外，减少ATIR翻译的MicroRNA155在出院后早期心源性死亡患者中升高。

项目成果

Weekly variation of circadian peaks for the onset of acute myocardial infarction in the working population

工作人群急性心肌梗死发病昼夜节律峰值的每周变化

• 发表时间: 2012
• 作者: Tanino Y;Shite J;et al.;Sato H
• 通讯作者: Sato H

Impact of Diabetes Mellitus on Rehospitalization for Heart Failure Among Survivors of Acute Myocardial Infarction in the Percutaneous Coronary Intervention Era

• DOI: 10.1253/circj.cj-08-0579
• 发表时间: 2009-04-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Nakatani, Daisaku;Sakata, Yasuhiko;Sato, Hiroshi
• 通讯作者: Sato, Hiroshi

Longitudinal risk of cardiovascular events in relation to depression symptoms after discharge among survivors of myocardial infarction

心肌梗死幸存者出院后抑郁症状与心血管事件的纵向风险

• 发表时间: 2011
• 期刊: Osaka Acute Coronary Insufficiency Study Circ J
• 作者: Shiozaki M;Iso H;Ohira T;Nakatani D;Shimizu M;Sakata Y;Komuro I;Sato H
• 通讯作者: Sato H

急性心筋梗塞患者の予後と退院後管理:近年の動向

急性心肌梗死患者的预后和出院后管理：最新趋势

• 发表时间: 2011
• 作者: 八尾武憲;伊藤誠;et al;佐藤洋
• 通讯作者: 佐藤洋

SNPs in BRAP associated with risk of myocardial infarction in Asian populations

• DOI: 10.1038/ng.326
• 发表时间: 2009-03-01
• 期刊: NATURE GENETICS
• 影响因子: 30.8
• 作者: Ozaki, Kouichi;Sato, Hiroshi;Tanaka, Toshihiro
• 通讯作者: Tanaka, Toshihiro