Role of Mitochondria on Platelet Activation Contributing to the Onset of Acute Myocardial Infarction
Role of Mitochondria on Platelet Activation Contributing to the Onset of Acute Myocardial Infarction
批准号:
21590911
负责人:
GOTO Shinya
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Platelets play crucial role in the onset of acute myocardial infarction. Platelets are active cells in view of energetic metabolism with several mitochondria. This study attempts to clarify the role of mitochondria in platelet cells for the onset of acute myocardial infarction.Mitochondria need oxygen to express their physiological function. Platelets in arterial blood containing high oxygen concentration have higher thrombogenicity than those in venous blood. The number and localization of mitochondria was not influenced by platelet activation. Cyclic increase in intracellular concentration of calcium ion induced by platelet activation was inhibited when the function of mitochondria was blocked.
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Disturbed blood flow induces erosive injury to smooth muscle cell-rich neointima and promotes thrombus formation in rabbit femoral artery.
血流紊乱会对富含平滑肌细胞的新内膜造成侵蚀性损伤,并促进兔股动脉血栓形成。
DOI:
--
发表时间:
2010
期刊:
J Thromb Haemost. 8
影响因子:
--
作者:
[Sumi T, Yamashita A, Matsuda S, Goto S, Nishihira K, Furukoji E, Sugimura H, Kawahara H, Imamura T, Kitamura K, Tamura S, Asada Y.]
通讯作者:
Asada Y.
Important regulatory role of activated platelet-derived procoaulant activity in the propagation of thrombi formed under arteiral blood flow conditions
活化的血小板衍生的促凝血活性在动脉血流条件下形成的血栓传播中的重要调节作用
DOI:
--
发表时间:
期刊:
Circulation Journal 73
影响因子:
--
作者:
[Tamura N, Kitajima I, Kawamura Y, Toda E, Eguchi Y, Ishida H, Goto S]
通讯作者:
Goto S
Imaging of structural changes in endothelial cells and thrombus formation at the site of FeCl(3)-induced injuries in mice cremasteric arteries.
小鼠提睾动脉 FeCl(3) 诱导损伤部位内皮细胞结构变化和血栓形成的成像。
DOI:
--
发表时间:
2009
期刊:
J Atheroscler Thromb 16(6)
影响因子:
--
作者:
[Kawamura Y, Takahari Y, Tamura N, Eguchi Y, Urano T, Ishida H, Goto S]
通讯作者:
Goto S
Inappropriate utilization of Anticoagulation in Patients With Atrial Fibrillation : The Global Anticoagulant Registry in the FIELD (GARFIELD) Registry
心房颤动患者抗凝治疗的不当使用:全球抗凝药物注册中心 (GARFIELD) 注册中心
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Gregory Lip, Jean-Pierre Bassand, David Fitzmaurice, Samuel Goldhaber, Goto S, Freek Verheugt, Alexander Turpie, Iris Mueller, Sophie Rushton-Smith, Ajay Kakkar]
通讯作者:
Ajay Kakkar
我が国における大規模臨床試験の発展に向けて
迈向日本大规模临床试验的发展
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Shinsuke Mikami, Yukihito Higashi, Yuichi Fujii, Naomi Idei, Noritaka Fujimura, Takayuki Hidaka, Tatsuya Maruhashi, Yumiko Iwamoto, Yasuki Kihara, Ikeda T, 後藤信哉]
通讯作者:
後藤信哉
共 41 条
Proposal of Molecular Leverage Hypothesis with Molecular Dynamic Calculation
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批准号:17K19669
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.08万
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财政年份:2017
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负责人:GOTO Shinya
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依托单位:
Constructive Understanding of the Platelet Function for the Onset of Myocardial Infarction.
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批准号:24390202
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.32万
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财政年份:2012
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负责人:GOTO Shinya
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依托单位:
Characteristics and prognosis of the elderly of using day care in the public-care insurance who tend to housebound
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批准号:19700433
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$0.36万
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财政年份:2007
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负责人:GOTO Shinya
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依托单位:
Role of platelet derived microparticle in the local regulation of vessel function
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批准号:19590871
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2007
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负责人:GOTO Shinya
-
依托单位:
Clarification of the Mechanism of Arterial Thrombus Formation by Dynamic Functional Imaging of Platelets
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批准号:17590764
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:GOTO Shinya
-
依托单位:
Mechanism of Procoagulant Activity Appearing on the Surface of Activated Platelet and New Development of Anttithrombotic Therapy by Its Inhibition.
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批准号:15590771
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2003
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负责人:GOTO Shinya
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依托单位:
The mechanism of platelet thrombus formation at site of endothelial damage under blood flow conditions
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批准号:13670744
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:2001
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负责人:GOTO Shinya
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依托单位:
海外基金