Evaluation of assessment method of renal microcirculation dysfunction using pressure wire, Doppler guide wire and NO catheter.

压力导丝、多普勒导丝和NO导管评估肾微循环功能障碍方法的评价

• 批准号: 21590915
• 负责人: NEISHI Yoji
• 金额: $ 2.91万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590915/
• 关键词: 腎動脈狭窄症; 腎動脈インターベンション; 高血圧; 腎機能障害; ドプロガイドワイヤー; 血管内超音波; 腎動脈プラーク; プラーク組織性状

The purpose of this study was to investigate whether renal flow reserve(RFR) and renal resistance index(RI) after percutaneous renal angioplasty(PTRA) correlate with renal function late after PTRA.RFR was defined as renal artery averaged peak velocity(APV) using a Doppler guide wire(FloWire, Volcano therapeutics, USA) during hyperemia divided by that at baseline. RI was calculated as the ratio of mean blood pressure to APV at hyperemia. The relationship between RFR and creatinine clearance(CCr), blood pressure, the number of anti-hypertensive drugs at follow-up was investigated.During follow-up, CCr, blood pressure, and the number of anti-hypertensive drugs did not change significantly. Ccr at follow-up was significantly higher in patients with high(>=1.9) RFR than low(<1.9) RFR.(41.2±15.3 vs. 49.6±12.9, p=0.045) Ccr at follow-up was higher in patients with low(<=2.7) RI than high(> 2.7) RI.(51.2±8.8 vs. 30.0±11.2, p=0.012)Renal flow reserve and renal resistance index immediately after PTRA may predict renal functional late after PTRA.

本研究旨在研究经皮肾血管成形术（PTRA）后肾血流储备（RFR）和肾阻力指数（RI）是否与PTRA后晚期肾功能相关。RFR定义为充血期间使用多普勒导丝（FloWire，火山治疗，美国）测量的肾动脉平均峰值流速（APV）除以基线值。RI计算为充血时平均血压与APV的比值。研究了RFR与肌酐清除率（CCr）、血压、随访时降压药物数量的关系，随访期间CCr、血压、降压药物数量无明显变化。高RFR（>=1.9）患者随访时的Ccr显著高于低RFR（<1.9）患者。(41.2±15.3 vs. 49.6±12.9，p=0.045）随访时低RI（<=2.7）患者的Ccr高于高RI（> 2.7）患者。(51.2±8.8 vs. 30.0±11.2，p=0.012）PTRA后即刻的肾血流储备和肾阻力指数可预测PTRA后晚期的肾功能。

项目成果

腎動脈狭窄症に対する経皮的腎動脈形成術後のRenal Flow ReserveおよびRenal Resistance Indexと慢性期腎機能

肾动脉狭窄经皮肾动脉成形术后肾流量储备和肾阻力指数及慢性期肾功能

• 发表时间: 2011
• 作者: Hoshida K;et al.;根石陽二
• 通讯作者: 根石陽二

Renal Flow Reserve and Renal Resistance Index after Percutaneous Renal Angioplasty Predict Renal Function late (12 months) after PTRA

经皮肾血管成形术后的肾流量储备和肾阻力指数可预测 PTRA 术后晚期（12 个月）的肾功能

• 发表时间: 2011
• 作者: Ahsung Kim;Kayoko Sato;et al;Yoji Neishi
• 通讯作者: Yoji Neishi

Relationship between Plaque Characteristics of the Renal Artery and the Distance from the Ostium in Patients with Renal Artery Stenosis

肾动脉狭窄患者肾动脉斑块特征与距肾口距离的关系

• 发表时间: 2010
• 作者: Ahsung Kim;Kayoko Sato;et al;Yoji Neishi;根石陽二
• 通讯作者: 根石陽二

Coronary microvascular endothelial function deteriorates late (12 months) after sirolimus-eluting stent implantation.

西罗莫司洗脱支架植入后晚期（12 个月）冠状动脉微血管内皮功能恶化。

• 发表时间: 2010
• 期刊: J Cardiol 56(2)
• 作者: Miyamoto Y;Okura H;Kume T;Kawamoto T;Neishi Y;Hayashida A;Yamada R;Imai K;Obase K;Yoshida K
• 通讯作者: Yoshida K

Assessment of the coronary calcification by optical coherence tomography

• DOI: 10.4244/eijv6i6a130
• 发表时间: 2011-01-01
• 期刊: EUROINTERVENTION
• 影响因子: 6.2
• 作者: Kume, Teruyoshi;Okura, Hiroyuki;Yoshida, Kiyoshi
• 通讯作者: Yoshida, Kiyoshi