Immunomodulatory role of PGD2/CRTH2 pathway in the pathophysiology of refractory lung diseases
Immunomodulatory role of PGD2/CRTH2 pathway in the pathophysiology of refractory lung diseases
批准号:
21590971
负责人:
ASANO Koichiro
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Previous studies by us and other researchers have clarified the role of PGD2 receptor, CRTH2, on allergic diseases including asthma by the activities on eosinophils and Th2 lymphocytes. In the present study, we have demonstrated that PGD2/CRTH2 pathway plays an essential role in the pathophysiology of chronic asthma, pulmonary fibrosis, and sepsis by modulating gamma-delta T cells and neutrophils.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Prostaglandin D_2 receptor, CRTH2, is critical for gamma-delta T cell-mediated suppression of pulmonary inflammation/fibrosis induced by bleomycin
前列腺素 D_2 受体 CRTH2 对于 γ-δ T 细胞介导的博来霉素诱导的肺部炎症/纤维化抑制至关重要
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[K Asano, S Ueda, M Ishii, Y Suzuki, K Fukunaga, T Oguma, M Nakamura, K Nagata, H Hirai]
通讯作者:
H Hirai
Asano Prostaglandin D_2 receptor CRTH2 is a critical regulator in a mice model of polymicrobial sepsis
Asano 前列腺素 D_2 受体 CRTH2 是多种微生物败血症小鼠模型的关键调节因子
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[M Ishii, N Hasegawa, H Namkoong, S Kagawa, M Nakamura, H Hirai, K Nagata, S Tasaka K]
通讯作者:
S Tasaka K
PGD2受容体CRTH2を介する肺臓炎・線維化抑制の分子機序
PGD2受体CRTH2抑制肺炎和纤维化的分子机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[上田壮一郎, 浅野浩一郎, 加川志津子, 田中希布人、滝原崇久, 福永興壱, 小熊剛, 佐山宏一]
通讯作者:
佐山宏一
プロスタグランジンD_2受容体CRTH2を介したブレオマイシン肺臓炎の炎症制御機構
前列腺素D_2受体CRTH2介导的博莱霉素肺炎炎症控制机制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[上田壮一郎, 浅野浩一郎, 加川志津子, 田中希布人、滝原崇久, 福永興壱, 小熊剛, 佐山宏一, 石坂彰敏]
通讯作者:
石坂彰敏
プロスタグランジンD_2と受容体
前列腺素 D_2 和受体
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[T.Numata, K.Nakayama, et al, 浅野浩一郎]
通讯作者:
浅野浩一郎
共 20 条
Identification of the causative fungus of fungus-related allergic airway diseases
-
批准号:19K08893
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2019
-
负责人:ASANO Koichiro
-
依托单位:
Mycobiota in the airways of allergic bronchopulmonary mycosis
-
批准号:16K09925
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2016
-
负责人:ASANO Koichiro
-
依托单位:
Metabolomics-based molecular phenotyping of severe asthma
-
批准号:25461504
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.16万
-
财政年份:2013
-
负责人:ASANO Koichiro
-
依托单位:
Prostaglandin D2 and its receptors in the pathogenesis of refractory inflammatory pulmonary diseases
-
批准号:19590912
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2007
-
负责人:ASANO Koichiro
-
依托单位:
Study on Estimations of Earthquake Ground motion models and Damage Preventions of Building Structures in Kansai Area
-
批准号:17560524
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.11万
-
财政年份:2005
-
负责人:ASANO Koichiro
-
依托单位:
Genetic factors that determine the responsiveness to platelet activating factor and their association with asthma
-
批准号:12670573
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.11万
-
财政年份:2000
-
负责人:ASANO Koichiro
-
依托单位:
Seismic reliability analysis of structural systems based on random ground motion model considering fault rupture process
-
批准号:09650642
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:1997
-
负责人:ASANO Koichiro
-
依托单位:
Research of Seismic Reliability Analysis of Structural Systems
-
批准号:01550454
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:1989
-
负责人:ASANO Koichiro
-
依托单位:
海外基金