Pathogenesis and drug development using a mouse model of chronic obstructive pulmonary disease
Pathogenesis and drug development using a mouse model of chronic obstructive pulmonary disease
批准号:
21590974
负责人:
ISHIGAMI Akihito
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We examined the effect of vitamin C depletion in lung from vitamin C depleted SMP30/GNL knockout mice by histopathologic and morphologic evaluations. Our results suggest that vitamin C protects lungs from oxidative stress and age-related lung diseases including cigarette smoke-induced chronic obstructive pulmonary disease(COPD).
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Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis
通过 ERK 介导的星形细胞增多,红藻氨酸诱导的海马损伤中衰老标记蛋白 30 上调
DOI:
10.1002/jnr.22122
发表时间:
2009
期刊:
J. Neurosci. Res
影响因子:
--
作者:
[Son, T. G., Park, H. R., Kim, S. J., Kim, K., Kim, MS., Ishigami, A., Handa, S., Maruyama, N. Chung, H. Y. and Lee, J]
通讯作者:
J
Time course of vitamin C distribution and absorption after oral administration into SMP30/GNL knockout mice
SMP30/GNL敲除小鼠口服后维生素C分布和吸收的时程
DOI:
--
发表时间:
2011
期刊:
Nutrition
影响因子:
4.4
作者:
[Iwama, et.al.]
通讯作者:
et.al.
ビタミンC欠乏がカテコールアミン生合成系に及ぼす影響
维生素C缺乏对儿茶酚胺生物合成系统的影响
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[天野晶子, 角田誠, 相垣敏郎, 丸山直記, 石神昭人]
通讯作者:
石神昭人
ヒトSMP30のX線結晶構造解析
人SMP30的X射线晶体结构分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[相澤真悟, 千田美紀, 相垣敏郎, 丸山直記, 石神昭人, 千田俊哉]
通讯作者:
千田俊哉
Establishment and characterization of hepatocytes from an Immortomouse/SMP30/GNL knockout mouse hybrid lacking vitamin C to study vitamin C transport
缺乏维生素 C 的 Immortomouse/SMP30/GNL 敲除小鼠杂交肝细胞的建立和表征,用于研究维生素 C 转运
DOI:
10.1093/jb/mvr109
发表时间:
2011
期刊:
Journal of biochemistry
影响因子:
2.7
作者:
[Amano, A., Handa, S., Aigaki, T., Shigemoto, K., Maruyama, N., Ishigami, A.]
通讯作者:
A.
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Development of diagnostic agent for dementia
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批准号:24659169
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2012
-
负责人:ISHIGAMI Akihito
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依托单位:
Effect of vitamin C deficiency on the fetal growth and aging
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批准号:24380073
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.48万
-
财政年份:2012
-
负责人:ISHIGAMI Akihito
-
依托单位:
The elucidation of onset mechanism of Alzheimer's disease.
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批准号:18590355
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:2006
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负责人:ISHIGAMI Akihito
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依托单位:
Molecular pathological analysis of citrullinated proteins in the brain from neurodegenerative disorder patients.
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批准号:14570210
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2002
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负责人:ISHIGAMI Akihito
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依托单位:
海外基金