Cancer antigen WT1-targeting peptide vaccine therapy for lung cancer

肺癌抗原WT1靶向肽疫苗治疗

• 批准号: 21590991
• 负责人: OKA Yoshihiro
• 金额: $ 3万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590991/
• 关键词: WT1; 肺癌; 癌免疫療法; ペプチドワクチン; 免疫療法; 胸腺腫

We accumulated cases with lung cancer treated by WT1 peptide vaccine. We analyzed anti-WT1 antibody in nonsmall cell lung cancer patients, which showed the existence of immune response against WT1 protein in the lung cancer. We analyzed WT1-specific CTLs in bone marrow(BM) of cancer-bearing patients, which indicated the possibility that BM had a role as a secondary lymhpoid organ in cancer immunity. We analyzed WT1 helper peptide-specific response of CD4^+ T cells, which suggested an important role of Th response in cancer immunity. We demonstrated, using a mice model, that co-administration of WT1 peptide vaccine and IFN-βwas a promising novel therapy for cancer. Biased usage of TCR BV gene families of WT1-specific CD8^+ T cells in patients with solid tumors and healthy donors was shown.

我们积累了用WT 1肽疫苗治疗肺癌的病例。我们分析了非小细胞肺癌患者的抗WT 1抗体，表明肺癌中存在针对WT 1蛋白的免疫应答。我们分析了癌症患者骨髓（BM）中的WT 1特异性CTL，这表明BM在癌症免疫中作为次级类人猿器官的可能性。我们分析了CD 4 ^+ T细胞的WT 1辅助肽特异性反应，这表明Th反应在癌症免疫中的重要作用。我们使用小鼠模型证明，WT 1肽疫苗和IFN-β联合给药是一种有前途的新型癌症治疗方法。在实体瘤患者和健康供体中，WT 1特异性CD 8 ^+ T细胞的TCR BV基因家族的使用存在偏倚。

项目成果

膠芽腫に対するWT1ペプチドワクチン療法における長期生存例と予後予測因子

WT1肽疫苗治疗胶质母细胞瘤的长期生存病例和预后因素

• 发表时间: 2010
• 作者: 橋本直哉、岡芳弘;ら
• 通讯作者: ら

WT-1 peptide vaccine

WT-1肽疫苗

• 发表时间: 2009
• 作者: 小山信之;張嘉玲;呼群;石川雄一;小林国彦;萩原弘一;檜山桂子;岡芳弘
• 通讯作者: 岡芳弘

Effects of Concomitant Temozolomide and Radiation Therapies on WT1-specific T-cells in Malignant Glioma

• DOI: 10.1093/jjco/hyp196
• 发表时间: 2010-05-01
• 期刊: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 2.4
• 作者: Chiba, Yasuyoshi;Hashimoto, Naoya;Yoshimine, Toshiki
• 通讯作者: Yoshimine, Toshiki

Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheral blood in patients with myelodysplastic syndromes.

• DOI: 10.1016/j.leukres.2009.11.029
• 发表时间: 2009-11
• 期刊: Leukemia research
• 影响因子: 2.7
• 作者: H. Tamura;K. Dan;N. Yokose;R. Iwakiri;M. Ohta;H. Sakamaki;K. Tohyama;A. Kondo;Hideya Hyodo;Kyoko Nakamura;T. Yamashita;O. Elisseeva;Y. Oka;Y. Oji;H. Sugiyama;K. Ogata

WT1 IgG antibody for early detection of nonsmall cell lung cancer as its prognostic factor

WT1 IgG 抗体用于早期检测非小细胞肺癌作为其预后因素

• 发表时间: 2009
• 期刊: International Journal of Cancer 125
• 作者: Oji Y.;Kitamura Y.;et al
• 通讯作者: et al