Molecular mechanisms and roles of cell senescence in lung injury and repair

我们在特发性肺纤维化（IPF）患者的肺组织中发现支气管和肺泡上皮细胞衰老，但成纤维细胞没有衰老。这些结果表明，每种类型细胞对微环境的反应性差异导致组织重塑和肺纤维化。 TGF-β 诱导人原代培养的支气管上皮细胞的细胞衰老，而 SIRT6 则抑制它。抑制上皮细胞衰老可能会导致预防肺纤维化。

We found bronchial and alveolar epithelial cell senescence in lung tissues from patients with idiopathic pulmonary fibrosis(IPF), but not fibroblast senescence. These results suggest that the difference of responsiveness to microenvironment in each type of cells leads to tissue remodeling and pulmonary fibrosis. TGF-beta induced cell senescence in human primary cultured bronchial epithelial cells and SIRT6 inhibited it. To inhibit epithelial cell senescence may leads to prevent pulmonary fibrosis.