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New approach for the diabetic nephropathy using the inhibition by GSK3

New approach for the diabetic nephropathy using the inhibition by GSK3
利用 GS​​K3 抑制治疗糖尿病肾病的新方法
批准号:
21591034
负责人:
NAKAYAMA Yushi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Diabetes mellitus was induced by STZ administration to the SD rat. The 2 Z, 3 E-6-bromoindirubin-3-oxime(BIO), a GSK-3 s inhibitor, was administrated peritoneally. In diabetic rat the urinary protein excretion was reduced by BIO administration. The TGF-s1 mRNA expression of glomeruli was suppressed by BIO treatment. It was suggested that the suppression of TGF-s1 by BIO could be involved the amelioration of diabetic nephropathy.
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DOI: 10.1038/hr.2009.52
发表时间: 2009-08
期刊: Hypertension Research
影响因子: 5.4
作者: [S. Wakamatsu;H. Nonoguchi;M. Ikebe;K. Machida;Y. Izumi;Hasiyet Memetimin;Y. Nakayama;T. Nakanishi;Y. Kohda;K. Tomita]
通讯作者: S. Wakamatsu;H. Nonoguchi;M. Ikebe;K. Machida;Y. Izumi;Hasiyet Memetimin;Y. Nakayama;T. Nakanishi;Y. Kohda;K. Tomita
DOI: 10.1038/hr.2009.19
发表时间: 2009-05
期刊: Hypertension Research
影响因子: 5.4
作者: [T. Mouri;Takeaki Inoue;H. Nonoguchi;Y. Nakayama;Hiroki Miyazaki;T. Matsuzaki;H. Saito;T. Nakanishi;Y. Kohda;K. Tomita]
通讯作者: T. Mouri;Takeaki Inoue;H. Nonoguchi;Y. Nakayama;Hiroki Miyazaki;T. Matsuzaki;H. Saito;T. Nakanishi;Y. Kohda;K. Tomita
腎性貧血の管理について、若手医師のための透析診療のコツ
年轻医生治疗肾性贫血的透析治疗技巧
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Nonoguchi H, 他, 斉藤亮彦, 中山裕史, 佐々木基史, 中山裕史, Koyama A, 中山裕史]
通讯作者: 中山裕史
A case with acute renal failure and subsequent nephrotic syndrome.
急性肾功能衰竭继发肾病综合征一例。
DOI: --
发表时间: 2009
期刊: Renal Fail 31
影响因子: --
作者: [Nonoguchi H, Kohda Y, Nakanishi T, Fukutomi R, Nakayama Y, Naruse M, Kitamura K, Inoue T, Nakanishi T, Tomita K.]
通讯作者: Tomita K.
9
    Analysis of the action and the mechanism of vasopressin via V1aR in the kidney, and the search for the new antidiuretic peptide
    • 批准号:
      19590957
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2007
    • 负责人:
      NAKAYAMA Yushi
    • 依托单位:
    海外基金