The development for new peritoneal dialysate to reduce oxidative stress and apoptosis using rare sugar

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In order to clarify the protective fluid in peritoneal dialysis(PD), we investigated the effects of psicose, one of rare sugars, on peritoneal mesothelial cells(PMCs)injury induced by D-glucose. ROS production was significantly increased in PMCs treated with 83mM D-glucose containing medium. Both D-and L-psicose prevented the D-glucose induced ROS production via suppression of p22 phox, a NADPH oxidase membrane component. These results suggested that decrease of ROS production was possible mechanisms that psicose suppressed peritoneal deterioration. Then, we are focus the medical relevance in vivo animal models. We conclude that psicose containing dialysate may be beneficial effect on PMCs survival in PD therapy ; however it will be necessary to proof the concept in vivo animals.