Research in a experimental and clinical significance of uPAR as a new therapeutic target molecule for diabetic nephropathy

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We investigated the role of uPAR as a new therapeutic molecule for diabetic nephropathy. The uPAR knockout mice fed 60% high-fat diet for 12 weeks showed the decrease of body weight, serum insulin levels, serum leptin levels, and the expression levels of fibronectin and type IV collagen in the kidney, whereas albuminuria was not different. In the long follow-up observational study(median : 12 years) including 186 patients with type 2 diabetes, the subgroup with higher levels of serum soluble uPAR showed the higher cumulative incidence of renal dysfunction and cardiovascular events. Thus, these results suggest that uPAR associates with renal dysfunction in diabetic patients.