Identifying a novel insulin-like hormone in a patient with fulminant type 1 diabetes using protein-protein interaction methods

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In patients with fulminant diabetes, the blood glucose levels are generally difficult to control because their endogenous insulin secretion are depleted from the onset. A patient with fulminant type 1 diabetes shows excellent glycemic control with small amount of exogenous insulin injection. This rare case leads us to hypothesize that an unknown insulin-like hormone will exist in this patient's blood. To explore this hypothesis, we have performed preliminary experiments of protein-protein interaction using human recombinant insulin receptor, although the results were not expected.