The study of the interactions between muscle and bone/mineral metabolism.

研究肌肉和骨/矿物质代谢之间相互作用的学科。

• 批准号: 21591179
• 负责人: KAJI Hiroshi
• 金额: $ 2.83万
• 依托单位: Kinki University (2011)Kobe University (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591179/
• 关键词: 筋; 骨; 骨芽細胞; 分化; シグナル; 筋肉; 副甲状腺ホルモン; BMP-2

The aim of our study is the identification of local ossification factors in muscle tissues and humoral bone anabolic factors produced from muscles in order to clarify the interactions between muscle and bone/mineral metabolism. We selected the factors with bone formation activity using the comprehensive gene analysis between muscle-derived cells and ossification signal-enhanced cells. Among them, Tmem119 is expected the factor, which locally induces muscle ossification. On the other hand, osteoglycin and FAM5C may be the candidates of novel humoral bone anabolic factors produced from muscles. We would like to proceed the further study of these factors as the putative targets for the development of the treatment of osteoporosis.

本研究的目的是鉴定肌肉组织中的局部骨化因子和肌肉产生的体液骨合成代谢因子，以阐明肌肉和骨/矿物质代谢之间的相互作用。通过对肌源性细胞和成骨信号增强细胞的综合基因分析，筛选出具有成骨活性的因子。其中，Tmem 119被认为是局部诱导肌肉骨化的因子。另一方面，骨甘氨酸和FAM 5C可能是新的体液性骨合成代谢因子的候选者。我们希望进一步研究这些因素作为骨质疏松症治疗发展的假定靶点。

项目成果

PTH及びSmad3シグナルにより誘導される新規因子Tmem119は骨芽細胞の分化を促進する

PTH 和 Smad3 信号诱导的新因子 Tmem119 促进成骨细胞分化

• 发表时间: 2009
• 作者: Wang EL;Qian ZR;Rahman MM;Yoshimoto K;Yamada S;Kud o E;Sano T;比佐伊都子
• 通讯作者: 比佐伊都子

Menin interacts with ss-catenin in osteoblast differentiation

Menin 与 ss-catenin 在成骨细胞分化中相互作用

• DOI: 10.1055/s-0030-1270527
• 发表时间: 2011
• 期刊: Horm Metab Res
• 影响因子: 2.2
• 作者: Inoue Y;Hendy GN;Canaff L;Seino S;Kaji H
• 通讯作者: Kaji H

Novel parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation

新型甲状旁腺激素反应性 Smad3 相关因子 Tmem119 促进成骨细胞分化

• 发表时间: 2010
• 作者: 中川靖彦;岸田堅;Hisa I
• 通讯作者: Hisa I

Parathyroid Hormone-responsive Smad3-related Factor, Tmem119, Promotes Osteoblast Differentiation and Interacts with the Bone Morphogenetic Protein-Runx2 Pathway

• DOI: 10.1074/jbc.m110.179127
• 发表时间: 2011-03-18
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Hisa, Itoko;Inoue, Yoshifumi;Kaji, Hiroshi
• 通讯作者: Kaji, Hiroshi

Comparisons of Serum Sclerostin Levels among Patients with Postmenopausal Osteoporosis, Primary Hyperparathyroidism and Osteomalacia

• DOI: 10.1055/s-0031-1275661
• 发表时间: 2011-07-01
• 期刊: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
• 影响因子: 1.8
• 作者: Kaji, H.;Imanishi, Y.;Seino, S.
• 通讯作者: Seino, S.