Biological and functional analysis of SFRP1, a novel regulator on early process of lymphopoiesis

我们报道了妊娠期和高雌激素状态下，早期淋巴细胞生成暂停。通过深入分析雌激素对造血微环境的影响，我们发现可溶性卷曲相关蛋白1（SFRP 1）作为雌激素作用的介质。在本研究中，我们构建了SFRP 1或其他SFRP相关分子的转基因小鼠模型，以评估其在体内的生物学意义。我们已经观察到严重的白细胞减少症，特别是B淋巴细胞减少，在SFRP过表达的小鼠。

We reported that early lymphopoiesis is suspended during pregnant period and high-estrogen condition. By means of intensive analyses on the influence of estrogen on the hematopoietic microenvironment, we have found that soluble Frizzled-related protein 1(SFRP1) acts as a mediator of estrogen action. In the present study, we have constructed transgenic mouse models of SFRP1 or other SFRP-related molecules to evaluate their biological significance in vivo. We have observed severe leukocytopenia, particularly decrease of B-lymphocytes, in SFRP over-expressing mice.