Development of novel identification methods of SNPs responsible for minor H antigens and open public internet software tool

次要组织相容性抗原(H)是供体免疫细胞靶向的多态蛋白，用于治疗异体造血细胞移植后的血液恶性肿瘤。这种免疫反应是由于个体之间的遗传差异而产生的排斥反应。在这项研究中，我们开发了一种软件，可以有效地识别在大量snp中产生次要H抗原的单核苷酸多态性（snp），并将该软件作为研究人员友好的互动方式通过互联网提供。

Minor histocompatibility antigens(H) are polymorphic proteins targeted by donor immune cells to cure hematological malignancies following allogeneic hematopoietic cell transplantation. This immune response utilizes rejection reaction due to genetic disparities between individuals. In this study, we developed a software that can efficiently identify single nucleotide polymorphisms(SNPs) responsible for generation of minor H antigens among large number of SNPs and have made the software available via internet as researcher-friendly interactive manners.