Development of therapeutic strategies for RA targeting TNF-α-inducible RNA receptors in cytoplasm

开发针对细胞质中 TNF-α 诱导性 RNA 受体的 RA 治疗策略

• 批准号: 21591259
• 负责人: IMAIZUMI Tadaatsu
• 金额: $ 2.83万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591259/
• 关键词: リウマチ; ループス腎炎; RIG-I; MDA5; 細胞質RNA受容体; 慢性炎症; TLR3; IFN-β; DEC2; poly IC; ISG20; Th1; RIG-1; microRNA; IFN-γ; TNF-α; CCL5; microRNA-155; inflammation

Retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are TNF-α-inducible RNA receptors in cytoplasm. The expression of RIG-I and MDA5 are induced by viral infection, and are increased in chronic inflammatory diseases such as rheumatoid arthritis and lupus nephritis which can be triggered or worsened by viral infections. Knockdown of RIG-I and/or MDA5 resulted in the induction of inflammatory cytokines，and RIG-I and MDA5 can be molecules which can be new therapeutic targets.

视黄酸诱导基因i （RIG-I）和黑色素瘤分化相关基因5 （MDA5）是细胞质中TNF-α-诱导的RNA受体。rig - 1和MDA5的表达受病毒感染诱导，在慢性炎症性疾病如类风湿关节炎和狼疮肾炎中表达增加，这些疾病可由病毒感染引发或加重。rig - 1和/或MDA5的下调导致炎症细胞因子的诱导，rig - 1和MDA5可能成为新的治疗靶点。

项目成果

Melanoma Differentiation-Associated Gene 5 Regulates the Expression of a Chemokine CXCL10 in Human Mesangial Cells: Implications for Chronic Inflammatory Renal Diseases

• DOI: 10.1620/tjem.228.17
• 发表时间: 2012-09-01
• 期刊: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
• 影响因子: 2.2
• 作者: Imaizumi, Tadaatsu;Aizawa-Yashiro, Tomomi;Satoh, Kei
• 通讯作者: Satoh, Kei

IFN-γ and TNF-a synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells.

IFN-γ 和 TNF-a 协同诱导 microRNA-155，调节人系膜细胞中的 TAB2/IP-10 表达。

• 发表时间: 2010
• 期刊: Am J Nephrol
• 影响因子: 4.2
• 作者: Imaizumi T;Tanaka H;Tajima A;Yokono Y;Matsumiya T;Yoshida H;Tsuruga K;Aizawa-Yashiro T;Hayakari R;Inoue I;Ito E;Satoh K.
• 通讯作者: Satoh K.

IgA 免疫複合体沈着型腎炎症候群の尿沈査細胞から得られる炎症関連分子群 mRNA の検討：ウイルス感染症との関わり

IgA免疫复合物沉积性肾炎综合征尿沉渣细胞炎症相关分子组mRNA检测：与病毒感染的关系

• 作者: 敦賀和志;渡邉祥二郎;相澤知美;吉田秀見;今泉忠淳;田中完
• 通讯作者: 田中完

Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells

• DOI: 10.1016/j.virusres.2011.07.011
• 发表时间: 2011-09-01
• 期刊: VIRUS RESEARCH
• 影响因子: 5
• 作者: Okabayashi, Tamaki;Kojima, Takashi;Sawada, Norimasa
• 通讯作者: Sawada, Norimasa

Retinoic acid-inducible gene-I is induced by double-stranded RNA and regulates the expression of CCL5 in human mesangial cells.

视黄酸诱导基因-I 由双链 RNA 诱导，调节人系膜细胞中 CCL5 的表达。

• 发表时间: 2010
• 期刊: Nephrol Dial Transplant
• 作者: Imaizumi T;Tanaka H;Matsumiya T;Yoshida H;Tanji K;Tsuruga K;Oki E;Yashiro T;Ito E;Satoh K
• 通讯作者: Satoh K