Pathogenic role of newly identified regulatory molecule in autoimmune arthritis

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1)TIARP-/-mice developed spontaneous arthritis, had high serum levels of IL-6, increased CD11b+ cell count in the spleen, and showed enhanced TNF-induced IL-6 expression in macrophages. Sustained degradation of IkBa with dysregulated apoptosis was also noted in TIARP-/-macrophages, and they showed increased IL-6-induced STAT3 phosphorylation. These findings suggested that TIARP is a negative regulator in arthritis by suppressing IL-6 production, its signaling and TNFa-induced NF-kB signaling result in enhanced apoptosis in macrophages. 2)Nine cyclic citrullinated GPI peptides (CCG-1-9) were constructed. Samples were obtained from patients with RA (n=208), healthy subjects (n=174) and other autoimmune diseases (n=202). Anti-CCG-2, 4, 7 Abs were detected in about 30.0% patients with RA, and these Abs were very specific of RA (specificity 99%). Anti-CCG-2, 4, 7 Abs were correlated with anti-CCP, CEP-1 and the presence of HLA-DRB1 SE allele. Treatment with TNF antagonists significantly reduced the levels of anti-CCG-2, 7, suggesting possible diagnostic and activity marker of RA.