Experimental and Clinical studies of repair of intra-thoracic autonomic nerves using chitosan tubes

壳聚糖管修复胸内自主神经的实验与临床研究

• 批准号: 21591661
• 负责人: MATSUMOTO Isao
• 金额: $ 2.5万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591661/
• 关键词: キトサン; 神経再生; 横隔神経; 迷走神経; 交感神経

We investigated the safety and usefulness of chitosan nano/microfiber mesh tubes(C-tube) in regenerating damaged thoracic autonomic nerves. Animal experiments were performed using beagle dogs. The thoracic sympathetic nerve and phrenic nerve were resected and sutured with C-tubes. After surgery, all dogs survived without complication throughout the observational period. At1year after surgery, the nerves were connected in C-tube, and in some dogs the symptoms due to each damaged nerve were recovered. C-tubes can be safely used to facilitate the regeneration of damaged sympathetic and phrenic nerves and the restoration of their lost functions.

我们研究了壳聚糖纳米/微纤维网管（C-管）在再生受损胸部自主神经方面的安全性和有效性。使用比格犬进行动物实验。切除胸交感神经和膈神经，用C管缝合。手术后，所有狗在整个观察期间均存活，没有出现并发症。手术后一年，神经用C管连接，一些狗因神经受损而出现的症状得到了恢复。 C 形管可以安全地用于促进受损交感神经和膈神经的再生并恢复其失去的功能。

项目成果

Repair of intra-thoracic autonomic nerves using chitosan tubes

• DOI: 10.1510/icvts.2009.227744
• 发表时间: 2010-04-01
• 期刊: INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
• 作者: Matsumoto, Isao;Kaneko, Mami;Watanabe, Go
• 通讯作者: Watanabe, Go

ナノテクノロジーを応用したキトサンナノ繊維チューブによる横隔神経再生効果の検討

利用纳米技术检查壳聚糖纳米纤维管的膈神经再生效果

• 发表时间: 2010
• 作者: Matsumoto I;Kaneko M;Oda M;Watanabe G;松本勲
• 通讯作者: 松本勲