Experimental and Clinical studies of repair of intra-thoracic autonomic nerves using chitosan tubes

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We investigated the safety and usefulness of chitosan nano/microfiber mesh tubes(C-tube) in regenerating damaged thoracic autonomic nerves. Animal experiments were performed using beagle dogs. The thoracic sympathetic nerve and phrenic nerve were resected and sutured with C-tubes. After surgery, all dogs survived without complication throughout the observational period. At1year after surgery, the nerves were connected in C-tube, and in some dogs the symptoms due to each damaged nerve were recovered. C-tubes can be safely used to facilitate the regeneration of damaged sympathetic and phrenic nerves and the restoration of their lost functions.