The research of aspirin induced asthma associated with prostaglandin receptors

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Original plan was to analyse the role of the receptor of prostaglandin E2(EP)(kindly gifted from Ono pharmaceutical company) in murine model of asthma by using EP agonist, however, it found out that beraprost, the agonist of prostaglandin I2 receptor(IP) had potentials to suppress airway allergic inflammation more that EP agonists. Moreover, a novel IP agonist(kindly gifted from Ono pharmaceutical company) that has the inhibitory effects of thromboxane synthesis, induced significant suppression of airway hyperresponsiveness and airway eosinophilic inflammation in murine asthma mode. This mechanism appeared to be due to the alteration of lung dendritic cell functions.