The research of aspirin induced asthma associated with prostaglandin receptors

阿司匹林哮喘与前列腺素受体相关的研究

• 批准号: 21591280
• 负责人: KOYA Toshiyuki
• 金额: $ 2.91万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591280/
• 关键词: 気管支喘息; アスピリン喘息; プロスタグランジン; 動物実験; 気道過敏性; プロスタグランジンI2; トロンボキサン合成酵素阻害; 肝細胞増殖因子; 気道リモデリング; プロスタグランジンE2; 好酸球性気道炎症

Original plan was to analyse the role of the receptor of prostaglandin E2(EP)(kindly gifted from Ono pharmaceutical company) in murine model of asthma by using EP agonist, however, it found out that beraprost, the agonist of prostaglandin I2 receptor(IP) had potentials to suppress airway allergic inflammation more that EP agonists. Moreover, a novel IP agonist(kindly gifted from Ono pharmaceutical company) that has the inhibitory effects of thromboxane synthesis, induced significant suppression of airway hyperresponsiveness and airway eosinophilic inflammation in murine asthma mode. This mechanism appeared to be due to the alteration of lung dendritic cell functions.

原计划用EP激动剂分析前列腺素E2（EP）受体（赠送于Ono制药公司）在小鼠哮喘模型中的作用，但发现前列腺素E2受体（IP）激动剂伯拉前列素比EP激动剂更有抑制气道变应性炎症的潜力。此外，一种新型的IP激动剂（来自Ono制药公司）具有抑制血栓素合成的作用，在小鼠哮喘模式下诱导气道高反应性和气道嗜酸性粒细胞炎症的显著抑制。这一机制似乎是由于肺树突状细胞功能的改变。

项目成果

A Sustained-Release Prostacyclin Agonist With Thromboxane Inhibitory Activity(ONO-1301MS) Improves Airway Inflammation And Remodeling In A Murine Model Of Chronic House Dust Mite-Induced Airway Disease

具有血栓素抑制活性的缓释前列环素激动剂 (ONO-1301MS) 可改善慢性屋尘螨诱发的气道疾病小鼠模型中的气道炎症和重塑

• 发表时间: 2012
• 作者: Y. Kimura;T. Koya;H. Sakamoto;H. Kawakami;Y. Hoshino;T. Furukawa;T. Sakagami;T. Hasegawa;H. Kagamu;Y. Sakai;K. Matsumoto;E. Suzuki;I. Narita
• 通讯作者: I. Narita

A Sustained-Release Prostacyclin Agonist With Thromboxane Inhibitory Activity (ONO-1301MS) Improves Airway Inflammation And Remodeling In A Murine Model Of Chronic House Dust Mite-Induced Airway Disease

具有血栓素抑制活性的缓释前列环素激动剂 (ONO-1301MS) 可改善慢性屋尘螨诱发的气道疾病小鼠模型中的气道炎症和重塑

• 发表时间: 2012
• 作者: Kimura Y;Koya T;ほか11名
• 通讯作者: ほか11名

ONO-1301(PGI2アゴニスト+TX合成酵素阻害)のマウス慢性喘息モデルにおける気道過敏性の抑制効果

ONO-1301（PGI2激动剂+TX合酶抑制剂）对小鼠慢性哮喘模型气道高反应性的影响

• 发表时间: 2010
• 作者: Hasegawa H;Lei J;Matsumoto T;Onishi S;Suemori K;Yasukawa M;小屋俊之,河上英則,木村陽介,星野芳史,坂上拓郎,坂元宏隆,長谷川隆志,酒井芳紀,松本邦夫,中山瑞穂,鈴木栄一,成田一衛
• 通讯作者: 小屋俊之,河上英則,木村陽介,星野芳史,坂上拓郎,坂元宏隆,長谷川隆志,酒井芳紀,松本邦夫,中山瑞穂,鈴木栄一,成田一衛

A prostacyclin agonist with thromboxane inhibitory activity for airway allergic inflammation in mice

• DOI: 10.1111/j.1365-2222.2009.03418.x
• 发表时间: 2010-02-01
• 期刊: CLINICAL AND EXPERIMENTAL ALLERGY
• 影响因子: 6.1
• 作者: Hayashi, M.;Koya, T.;Gejyo, F.
• 通讯作者: Gejyo, F.

A Novel Prostacyclin Agonist Protects to Airway Hyperresponsiveness and Remodeling in Mice

新型前列环素激动剂可保护小鼠气道高反应性和重塑

• 发表时间: 2012
• 期刊: Am J Respir Cell Mol Biol
• 作者: Yamabayashi C;Koya T;Kagamu H;Kawakami H;Kimura Y;Furukawa T;Sakagami T;Hasegawa T;Sakai Y;Matsumoto K;Nakayama M;Gelfand EW;Suzuki E;Narita I
• 通讯作者: Narita I