The etiology of food allergy and inflammatory bowel diseases in children inrelation to peptides derived from digested food proteins.

为了研究儿童食物过敏和炎症性肠病（IBD）的病因与消化食物蛋白衍生的肽的关系，分析了其抗原性;然而，在食物过敏或IBD衍生的血清中未证实特异性反应。我们还采用微阵列、RT-PCR、免疫组化等方法研究了食物蛋白诱导的直肠结肠炎（FPIP）和IBD的粘膜样品，发现响应于CCL 11和CXCL 13信号传导的淋巴样增生伴嗜酸性粒细胞浸润到结肠粘膜中在FPIP中是重要的，而CXCL 9和CXCR 3是小儿IBD的关键分子。

To investigate the etiology of food allergy and inflammatory bowel diseases(IBD) in children in relation to peptides derived from digested food proteins, their antigenicity was analyzed ; however, no specific reactions were confirmed in serum derived from food allergy or IBD. We have also investigated the mucosal samples taken from food protein-induced proctocolitis(FPIP) and IBD with microarray, RT-PCR, immunohistochemistry and found that the lymphoid hyperplasia with eosinophilic infiltration into the colonic mucosa in response to CCL11 and CXCL13 signaling is important in FPIP while CXCL9 and CXCR3 are the key molecules in pediatric IBD.